Nature enthused algorithms are the most potent for optimization. Cuckoo Search (CS) algorithm is one such algorithm which is efficient in solving optimization problems in varied fields. This paper appraises the basic concepts of cuckoo search algorithm and its application towards the segmentation of brain tumor from the Magnetic Resonance Images (MRI). The human brain is the most complex structure where identifying the tumor like diseases are extremely challenging because differentiating the components of the brain is complex. The tumor may sometimes occur with the same intensity of normal tissues. The tumor, edema, blood clot and some part of brain tissues appear as same and make the work of the radiologist more complex. In general the brain tumor is detected by radiologist through a comprehensive analysis of MR images, which takes substantially a longer time. The key inventiveness is to develop a diagnostic system using the best optimization technique called the cuckoo search, that would assist the radiologist to have a second opinion regarding the presence or absence of tumor. This paper explores the CS algorithm, performing a profound study of its search mechanisms to discover how it is efficient in detecting tumors and compare the results with the other commonly used optimization algorithms.